pu的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列問答集和資訊懶人包

The Future Is Female! Vol. 2: 20 Classic Science Fiction Stories by Women Writer S of the 1970s: A Library of America Special Pu

為了解決pu的問題，作者 這樣論述：

Go back to the Future Is Female in this all new collection of wildly entertaining stories by the trailblazing feminist writers who transformed American science fiction in the 1970sImagine it, if you can bear to look back: long ago, in a galaxy far, far away, the writing of science fiction (so the st

ory goes) was an affair dominated by men, or what Ursula K. Le Guin once described as a ＂baboon patriarchy＂--its female characters figments of adolescent fantasy, awaiting rescue in bronze brassieres, to be mansplained to about rocketry and ray guns. Now cut to the 1970s--the coming-of-age decade fr

om which the 20 stories gathered here emerged--when it all changed. Following on The Future Is Female!, which traced the prehistory for women’s science fiction from the 1920s to the 1960s, The Future Is Female! Vol. 2 presents the astonishingly brave and compelling stories of the women who remade th

e genre in the 1970s, including: - Octavia E. Butler, ＂Childfinder＂ (1970)- Sonya Dorman, ＂Bitching It＂ (1971) - Kate Wilhelm, ＂The Funeral＂ (1972)- Joanna Russ, ＂When It Changed＂ (1972) NEBULA AWARD - Miriam Allen deFord, ＂A Way Out＂(1973)- Vonda N. McIntyre, ＂Of Mist, and Grass, and Sand＂ (1973) N

EBULA - James Tiptree, Jr., ＂The Girl Who Was Plugged In＂ (1973) HUGO AWARD - Kathleen Sky, ＂Lament of the Keeku Bird＂ (1973)- Ursula K. Le Guin, ＂The Day Before the Revolution＂ (1974) NEBULA & LOCUS AWARD - Phyllis Eisenstein, ＂Attachment＂ (1974)- Eleanor Arnason, ＂The Warlords of Saturn’s Moons＂ (

1974)- Kathleen M. Sidney, ＂The Anthropologist＂ (1975)- Marta Randall, ＂A Scarab in the City of Time＂ (1975) - Elinor Busby, ＂A Time to Kill＂ (1977)- Raccoona Sheldon, ＂The Screwfly Solution＂ (1977) NEBULA AWARD - Pamela Sargent, ＂If Ever I Should Leave You＂ (1974)- Joan D. Vinge, ＂View from a Heigh

t＂ (1978)- M. Lucie Chin, ＂The Best Is Yet to Be＂ (1978)- Lisa Tuttle, ＂Wives＂ (1979) - Connie Willis, ＂Daisy, In the Sun＂ (1979) Lisa Yaszek, editor, is Professor in the School of Literature, Media, and Communication at Georgia Tech and past president of the Science Fiction Research Association.

She is the author of Galactic Suburbia: Recovering Women’s Science Fiction (2008), and coeditor of Sisters of Tomorrow: The First Women of Science Fiction (2016); she currently serves as a juror for the John W. Campbell Memorial Award for Best Science Fiction Novel of the Year and the Eugie Foster M

emorial Award for the Best Speculative Story of the Year.

pu進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決pu的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Geraldine Pu and Her Lucky Pencil, Too!: Ready-To-Read Graphics Level 3

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為了解決pu的問題，作者Chang, Maggie P. 這樣論述：

Maggie P. Chang grew up in Kansas, where she constantly had her nose in a book and art supplies close by. She began her career in art education, but after teaching the most fabulous and talented teens at LaGuardia Arts High School (a.k.a. the Fame school), she was inspired to follow her own passion

for children’s books. This Taiwanese American is the author-illustrator of the Geraldine Pu series and is also the cofounder of two education nonprofits. Maggie lives in California with her husband, their daughter, and their dog, Benihana.

布里斯洛中間體自由基反應機制之理論研究

為了解決pu的問題，作者謝明修 這樣論述：

含氮雜環卡賓（N-heterocyclic carbene）催化之化學反應中，布里斯洛中間體（Breslow intermediate）扮演重要的催化角色。布里斯洛中間體能以親核基（nucleophile）或自由基（radical）之形式參與反應。本論文探討布里斯洛中間體之自由基特性及形成機制（mechanism），其自由基可從氫自由基轉移或直接氧化形成。安息香縮合反應（benzoin condensation）中，布里斯洛中間體將氫原子轉移至苯甲醛（benzaldehyde）以形成自由基，此自由基可結合形成安息香產物，或排除反應之副產物，使其重新進入催化反應。唯此路徑之反應能障高於傳統非自

由基路徑。此研究亦探討四種布里斯洛中間體之不同電子組態的位能面。其中烯醇鹽（enolate）形式能產生偶極束縛態（dipole-bound state），此為產生自由基之新路徑；拉電子基（electron-withdrawing group）以及立體障礙基（bulky groups）可穩定基態。另外，我們亦研究布里斯洛中間體之碎片化（fragmentation）與重組（rearrangement）。布里斯洛中間體之催化反應可能因其碳氮鍵斷裂而中止，形成碎片。我們證實其反應中可以形成自由基，亦可形成離子。反應趨向之路徑與布里斯洛中間體之羥基的質子化型態有關。碎片化反應亦可視為轉酮醇酶（tran

sketolase）中之噻胺（thiamin）催化反應中之副反應；此研究證實轉酮醇酶透過限制布里斯洛中間體之結構與質子化型態，使其碳氮鍵斷裂需更高之反應能量，進而抑制此副反應。