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Head Held High

為了解決Today chord的問題，作者Patil, Vishwas Nangre 這樣論述：

Today, whenever decorated officer Vishwas Nangre Patil recalls the memories of Diwali from his childhood days, the sounds of the firecrackers often transform into the deafening grenade blasts from the night of 26/11. It was his grit, cultivated over the years from the neck-breaking labour of stud

ying for the UPSC exams, that had enabled him to power on and gun down the terrorists inside an aflame Taj Hotel during the 2008 Mumbai attacks. Head Held High, translated from the Marathi Mann Mein Hai Vishwas, is an account of IPS officer Vishwas Nangre Patil’s life-from his humble background, thr

ough school, college, long hours of studying for the UPSC examinations to the final selection for the IPS cadre and, eventually, his role in the counterterrorist operations during the Mumbai attacks. This nostalgic and authentic account of the most formative and challenging years of his life is sure

to strike a chord with the thousands who aspire to join the ranks of the Indian Civil Services.

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Integrative genomic network-based drug repositioning for allergic diseases

為了解決Today chord的問題，作者WIRAWAN ADIKUSUMA 這樣論述：

AbstractAllergy diseases are currently not totally cured, but treatment could reduce the symptoms and progress over time in many cases. Unfortunately, drug choice is limited, posing substantial challenges for drug discovery or utilizing the old drug for a new disease called repurposing drugs. Findi

ng a novel drug involves a lot of time, money, and effort. In addition to the high expense, the chances of a promising candidate compound becoming a US FDA-approved drug are low. Drug repositioning/repurposing is a method used to extend the effects of approved drugs or revitalize those that have fai

led, which will resolve these obstacles and problems. This thesis focuses on discovering potential treatments for allergy diseases based on an approach that integrates gene networks and genomics. Three diseases (atopic dermatitis (AD), asthma, and allergic contact dermatitis (ACD)) were included in

the study.In the first study, we investigated discover potential drugs repurposed for AD. Herein, the AD-associated SNPs were obtained from the GWAS catalog. We identified 70 AD risk loci, and 94 genes were found by extending the AD risk loci using HaploReg version 4.1 for Asian populations with r2

> 0.8. The scoring system was developed using six functional annotations to predict drug candidates optimally using in silico pipelines. Twenty-seven biological AD risk genes were identified and then mapped into 76 drug target genes using the STRING database. We identified 25 drug target genes that

overlap 53 drugs in DrugBank and Therapeutic Target Database. Interestingly, dupilumab was successfully found in this bioinformatics analysis of the 53 drugs. Dupilumab was known as one of the drugs available used for AD. This finding confirms the feasibility and reliability of gene-based drug repur

posing. Furthermore, ten drugs were identified with clinical or preclinical evidence that could be useful in AD. Specifically, we identified filgotinib and fedratinib with target JAK1 inhibitors that might be repurposed to AD because JAK1 is an essential potential target for AD.In the second study,

we conducted drug repositioning for asthma. This study used the GWAS and PheWAS databases to obtain asthma risk SNPs that could yield information that might help guide to drug repurposing process. We used five biological criteria to prioritize asthma-associated genes and develop biological risk cand

idates for drug repositioning. Our research identified 139 biological asthma risk genes and 64 drugs that target 22 of these genes. Noteworthy, reslizumab, mepolizumab, theophylline, dyphylline, aminophylline, oxtriphylline, and enprofylline are seven of 64 drugs successfully identified in this bioi

nformatic analysis as clinical use for asthma. In addition, we observed in a ClinicalTrial.gov and an intensive PubMed literature review 17 drugs in a clinical trial and preclinical study potentially useful for asthma. Additionally, 11 out of 40 candidate drugs were potential candidates to treat ast

hma. Notably, IL6R would be an ideal target for repurposing asthma drugs due to its high target scores. We found sarilumab and satralizumab to be the most potential candidate drugs for asthma using in silico drug repurposing.In the third study, we conducted our data mining analysis for drug targets

of ACD by integrating the differentially expressed genes (DEGs). We identified 370 DEGs, including 281 upregulated and 79 down-regulated genes. A GO and KEGG pathway were analyzed to determine the biological functions of genes and pathways involved in ACD. Then, using protein-protein interaction an

alysis, we clustered these genes and discovered 10 Hub genes that are deemed significant in our model. Additionally, we used the drug-gene interaction database to conduct a drug-gene interaction analysis of module genes. We discovered 14 drugs that might be used to prevent and cure ACD. Noteworthy,

among 14 drugs, two drugs are currently under clinical trials and three are off-label used for ACD. In addition, four anticancer drugs were identified as promising ACD therapy. However, due to the high risk of side effects, anticancer drugs were not considered for ACD drug repurposing in our study.

Through a transcriptomic-driven drug discovery approach, we identified five drugs (risperidone, diclofenac, loratadine, collagenase clostridium histolyticum, and ocriplasmin) as the most promising drug to be repositioned in ACD therapy.Overall, this study has provided the most promising candidate dr

ugs that have not been reported as anti-allergic and offer a valuable drug repurposing approach to provide empirical evidence for drug discovery of allergic diseases.Keywords: Atopic dermatitis, asthma, allergic contact dermatitis, bioinformatics, drug repurposing, functional annotations, genomic, t

ranscriptomic.

Ukulele: A Complete Guide for Beginners to Learn About the Ukulele With Music (How to Play Ukulele Chords Quickly and Easily fo

為了解決Today chord的問題，作者Heaps, Jacob 這樣論述：

Do you want to learn how to play the ukulele? Learn to play your first songs and tunes with this beginner’s guide!This book is a great and entertaining way to share music with your family and lay the groundwork that will get you playing your favorite songs in no time. A practical Chord Chart, dif

ferent strumming patterns and easy plucking patterns to accompany songs, make this book a must-have for anyone who plays the ukulele.Inside, you’ll find: - A brief history of the Ukulele, how it came to be and the different parts (including their purpose)- The different types and sizes of the Ukulel

e- Things to consider before buying the Ukulele- How to get started with your Ukulele to ensure you have a great start- How to read the Ukulele sheet music the right way- Getting right the Ukulele chords- The popular songs you can use to practice using the Ukulele- Some surefire tips for playing the

Ukulele like a pro- Great Ukuleles for beginners- And much more!This book’s information is intended to lay a solid foundation for individuals planning to start ukulele lessons. Read through and start your journey to becoming ukulele stardom. By the time you’re done with this book, you’ll already be

playing your favorite songs on the uke. Click the Buy Now button to get started today!

新冠肺炎疫情期間新媒體使用對於用餐行為意圖之影響

為了解決Today chord的問題，作者莊堡凱 這樣論述：

新型冠狀肺炎（COVID-19）在全球肆虐，世界衛生組織已將新冠肺炎明定為「國際關注的突發公共衛生事件」。民眾也在自身健康安全的考量之下，減少或暫停一切戶外休憩以及群聚活動，而觀光餐旅產業在此疫情影響下，更是受到巨大的影響與阻礙。儘管現今研究傾注心力探討新媒體於傳染病爆發中的作用，但是針對社會大眾使用新媒體接收疫情資訊後所引發的負面情緒以及後續的行為意圖仍有待釐清。故本研究之目的是將透過SOR理論檢視於疫情爆發期間，新媒體的使用是否將引發恐懼與憤怒，進而造成降低前往餐廳用餐之意圖。研究結果表明，在臺灣（N = 428）經常使用新媒體接收新冠肺炎資訊者會產生恐懼情緒，進而導致其降低前往餐廳用餐

之意圖。本研究結果亦指出，利用新媒體接收疫情資訊無法引發閱聽人憤怒的情緒，且用餐行為意圖不受憤怒情緒的影響。最後本研究提供餐飲業者實務策略以渡過艱難的疫情期間。