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Targeting Cellular Signalling Pathways in Lung Diseases

為了解決Surgical suture的問題，作者 這樣論述：

Dr. Kamal Dua is a Lecturer in the Discipline of Pharmacy at the Graduate School of Health, University of Technology Sydney (UTS), Australia. He has research experience of over 12 years in the field of drug delivery systems targeting inflammatory diseases. Dr Dua is also a Node Leader of Drug Delive

ry Research in the Centre for Inflammation at Centenary Institute/UTS, where the targets identified from the research projects are pursued to develop novel formulations as the first step towards translation into clinics. Dr Dua researches in two complementary areas; drug delivery and immunology, spe

cifically addressing how these disciplines can advance one another helping the community to live longer and healthier. This is evidenced by his extensive publication record in reputed journals. Dr. Dua’s research interests focus on harnessing the pharmaceutical potential of modulating critical regul

ators such as Interleukins and microRNAs and developing new and effective drug delivery formulations for the management of chronic airway diseases. He has published more than 80 research articles in peer-reviewed international journals and authored or co-authored 4 books. He is an active member of m

any national and international professional societies.Prof. Raimar Löbenberg holds a BS in Pharmacy from the Johannes Gutenberg-University in Mainz, Germany and received his PhD in Pharmaceutics from the Johann Wolfgang Goethe-University. His research interests are in Biopharmaceutics and inhalable

nanoparticles to treat lung diseases. He is a founder and Director of the Drug Development and Innovation Centre at the University of Alberta. He was president of the Canadian Society for Pharmaceutical Sciences 2014-2015 and a member of the United States Pharmacopeia Dietary Supplement Expert Commi

ttee. He is a Vice-chair of the Specialty Committee of Traditional Chinese Medicine in Pharmaceutics of the World Foundation of Chinese Medicine Science. He is a member of the Health Canada Scientific Advisory Committee on Pharmaceutical Sciences and Clinical Pharmacology.Prof. Ângela Cristina Malhe

iros Luzo is a full Professor from the Surgical Science Post Graduation Discipline at the Faculty of Medical Science Surgery Department, UNICAMP. She is an active researcher at the Biology Institute of the State University of Campinas (UNICAMP). She served as a member of the liver transplantation te

am and was responsible for the installation of the Umbilical Cord Blood Bank (BSCUP) at UNICAMP. She obtained her medical degree from Faculty of Medical Sciences of Jundiaí and holds Master and PhD degrees in the field of biology and cell therapy of umbilical cord blood stem cells from the Clinical

Medicine Department of the Faculty of Medical Science, UNICAMP. She has three licensed patents related to fibrin glue that allows the attachment of mesenchymal stromal stem cells in suture filaments providing a complete regeneration of enterocutaneous fistula, tracheal injury, and correction of uret

hral stenosis in animal models (rat, pig, and rabbit).Dr. Shakti Shukla is a trained microbiologist and completed his PhD in Medical Studies from the University of Tasmania. Dr Shukla has been actively involved in various aspects of chronic respiratory diseases, including the pathophysiology and imm

unology of respiratory diseases especially cigarette smoking-related chronic obstructive pulmonary disease (COPD), lung cancer, and asthma. Dr. Shukla’s primary research interest involves the crucial role of microorganisms, in particular bacteria, in the development, progression and exacerbations of

COPD/asthma. His more recent research focuses on understanding the role of gastrointestinal microbiomes in the progression of COPD and whether the gut microbes could be utilised as a potential treatment for COPD. Dr. Shukla has published more than 65 publications in last 6 years and has won Young I

nvestigator Award from Thoracic Society of Australia and New Zealand (Tasmania Branch) for his research.Dr. Saurabh Satija is currently working as Assistant Dean at School of Pharmaceutical Sciences and Division of Student Welfare, Lovely Professional University (LPU), India and also an academic wit

h Discipline of Pharmacy, Graduate School of Health, University of Technology, Sydney, Australia. He has extensive experience in the field of natural products research, drug development, analytical method development and nanotechnology based novel drug delivery systems. He has received various natio

nal and international awards, scholarships, and research grants. He also carries an impressive bibliography of scientific papers published in journals of international repute. He has more than 100 research publications and 2 patents published to his credit.

Surgical suture進入發燒排行的影片

DEVELOPMENT OF AN ELECTROSPUN MATERIAL FOR CELL ENCAPSULATION

為了解決Surgical suture的問題，作者NGUYEN THI ANH TU 這樣論述：

Background: Cell therapy has been greatly proposed as a potential therapy for many degenerative diseases. However, the therapeutic effectiveness of cell therapy is hampered by cell loss and anoikis after transplantation. Cell encapsulation by biomaterials is suggested as a useful tool to protect tr

ansplanted cell from host immune response.Aim:In this work, a modified microtube array membrane (MTAM) was proposed as a polymeric scaffold for cell encapsulation to prevent cell loss and matrix detachment-associated cell death. The aim was to develop improved scaffolds based on the MTAM platform us

ing a biocompatible, degradable polymer.Methods:Core-shell coaxial electrospinning was utilized to fabricate MTAMs. The scaffold development was investigated using two polymers: polysulfone (PSF) and poly(lactic-co-glycolic) acid (PLGA). The MTAMs were characterized by scanning electron microscopy (

SEM), goniometry, FTIR, tensile test and in vitro degradation test. The MTAMs were plasma treated and sterilized before cell loading. In this model, human dermal fibroblasts were resuspended in medium at a concentration of 1x104 cells/µl, stained with a long-term red fluorescent dye, then loaded int

o MTAMs by capillary force. 3D MTAMs culture were conducted under normoxic conditions and tracked using fluorescent microscopy. An in vivo biocompatibility experiment was conducted on B6 mice with five investigational groups including sham surgery alone, free PSF MTAM, free PLGA MTAM, cell-loaded ve

rsion of PSF and PLGA MTAMs. After seven and 43 days of implantation, blood samples and skin tissues were harvested and analyzed.Results:Several new methodologies and formulations were explored. PSF and PLGA MTAMs were successfully fabricated using a core-shell electrospinning technique. SEM images

revealed the structure and microfiber dimension of PSF MTAMs were around 60 x 100 µm and 35 x 90 µm in PLGA MTAMs. The scaffolds had abundant surface pores with diameters of greater than 600 nm. In vitro degradation test results showed that PSF MTAMs were highly stable in hydrated environment while

PLGA degraded quickly within two months. Human dermal fibroblasts were successfully encapsulated and viable for at least 20 days in both PSF and PLGA MTAMs. Animal experiment results showed that both types of MTAM showed the ability to retain donor cells following transplantation. The results sugges

t that degradable PLGA MTAMs were more biocompatible than PSF MTAMs, surprisingly resulting in longer cell retention than non-degradable PSF-based materials.Conclusion:The microtube array membrane (MTAM) platform allows for cell encapsulation and long-term survival. PSF and PLGA MTAMs both show pote

ntial as cell delivery devices with high compatibility and cell retention. PLGA MTAMs are biodegradable which allows for non-invasive removal of the implant. However, the therapeutic efficacy of cell-loaded MTAMs is still unknown. In the future, more in vivo experiments should be conducted to study

the effectiveness of encapsulated cell therapy in a specific disease models.

Complications in Arthroscopic Shoulder Surgery

為了解決Surgical suture的問題，作者 這樣論述：

Laurent Lafosse MD, is an Orthopaedic Surgeon specialising in upper limb extremity surgery at Clinique Générale in Annecy, France. Dr Lafosse is Chairman of Alps Surgery Institute, an International Private Shoulder School and Chairman & Organizer of Annecy Live Surgery International Advanced Course.

Dr Lafosse is recognised as a pioneer of modern shoulder surgery and has had numerous scientific papers published in international peer reviewed journals. He has delivered several keynote lectures at international conferences and is regarded as one of today’s world leaders in arthroscopic shoulder

reconstruction. In addition, Dr Lafosse has been recognised worldwide for his innovations in shoulder surgery, including the Lasso loop stitch, Arthroscopic suprascapular nerve release, Arthroscopic Latarjet procedure and the Lafosse suture knot. Jens D. Agneskirchner, MD, PhD, is an Orthopaedic Sur

geon specialising in accident and trauma surgery at the Gelenkchirurgie Orthopädie Hannover (GOH) clinic in Germany. He is author of more than 50 publications and 10 book chapters and has given more than 500 presentations and 50 live surgeries on national and international courses. Dr Agneskirchner

is listed as German expert for orthopaedic shoulder surgery in the ’Focus Aerzteliste’ and received a DonJoy Award for surgical research studies. His main areas of research include Arthroscopic coracoid transfer (latarjet) in the shoulder, Arthroscopic reconstruction of the rotator cuff, Anterior an

d posterior stabilization Arthrolysis, AC joint reconstruction and Partial and total shoulder replacement. Thibault Lafosse is a hand upper limb surgeon, practicing arthroscopy and microsurgery at the Clinique Générale d’Annecy. Dr Lafosse completed a travelling fellowship in Thailand in Microsurger

y/Brachial Plexus Surgery and Residencies at the University Hospitals of Paris including the Ambroise Paré hospital, Arthroscopic and sports surgery unit and the Children hospital Trousseau, Orthopedic and reconstructive pediatric surgery department.

矽膠3D列印應用至互動仿真教具於阻生智齒手術在下牙槽神經麻醉之設計研究

為了解決Surgical suture的問題，作者陳韻萱 這樣論述：

目錄指導教授推薦書...........i口試委員會審定書...........ii致謝...........iii中文摘要...........ivAbstract...........v第一章 緒論...........11-1 研究背景與動機...........11-2 研究目的...........31-3 論文架構...........3第二章 文獻回顧...........52-1 教具在醫學培訓上之貢獻...........52-1-1 目前醫療培訓之現況...........52-1-2 目前教具在醫療培訓之運用...........72-2 教具設計和製作與其臨床驗證..

.........82-3 3D 列印在醫學教具上的應用及優勢...........212-4 阻生智齒手術治療之簡介...........272-4-1 阻生智齒生成原因...........272-4-2 阻生智齒拔除手術治療 282-4-3 阻生智齒拔除手術後的併發症 34第三章 研究方法 403-1 使用者訪談 413-1-1 訪談對象與人數 413-1-2 訪談進行方式 413-1-3 研究工具...........423-1-4 訪談分析...........443-2 材料仿真特性測試...........453-2-1 測試材質樣品...........453-2-

2 實驗設備...........483-2-3 實驗設計與流程...........513-2-4 實驗測試分析...........523-3 材料仿真問卷及訪談回饋...........533-3-1 受測者...........533-3-1 材料仿真使用者分析...........55第四章 研究結果...........574-1 訪談結果...........574-1-1 牙科學院學生在手術培訓教學之現況...........584-1-2 阻生智齒臨床手術遇到的困難與併發症...........594-2 材料仿真訪談及問卷結果...........604-2-1 材料仿真問

卷結果...........604-2-2 材料仿真訪談結果...........664-3 材料仿真特性測試結果...........714-3-4 仿真材料硬度測試結果...........714-3-1 仿真材料韌度測試結果...........794-4 前測結論...........854-4-1 訪談結論...........854-4-2 材料仿真問卷分析結論...........864-4-3 材料仿真訪談分析結論...........864-4-4 材料仿真特性測試結論...........87第五章 阻生智齒手術模擬模型之開發設計...........905-1 模型仿真設

計...........905-1-1 下顎齒模仿真...........905-1-2 下顎牙齦構造仿真...........915-2 模型互動設計...........925-3 使用者測試結果...........93第六章 結論與未來展望...........956-1 研究結論...........956-2 未來展望...........96附錄A - 仿真矽膠材料使用者測試回饋問卷...........103圖目錄圖1-1 論文架構圖...........4圖2-1 醫學院進行大型動物實驗...........5圖2-2 同學互相練習...........6圖2-3 使用電腦斷

層掃描在軟件中進行圖像處理...........8圖2-4 3D渲染圖像模型設計過程，以及列印模型...........9圖2-5 模擬先天性心臟手術的過程...........9圖2-6 調查結果...........11圖2-7 右眼組織虛擬模型...........12圖2-8 由矽膠列印出來眼球、眼肌、視神經和創神經組織...........13圖2-9 培訓模型，以及帶有光學標記的手術模型及導航系統...........13圖2-10 培訓程序：通過手術導航驗證植體的位置...........14圖2-11 定量分析的實驗設置...........18圖2-12 縫合AO2的主動脈拉

伸棒...........18圖2-13 定性反饋...........19圖2- 14 3D列印機...........22圖2-15 矽膠3D列印機...........22圖2-16 用3D列印兔唇教具...........23圖2-17 用3D列印斜視手術教具...........24圖2-18 3D列印教具與兔頭進行比較...........25圖2-19 阻生智齒...........28圖2-20 因牙骨質增生造成具有蘑菇狀的根...........29圖2-21 手術程序...........30圖2-22 將牙齒利用切牙術分為三個部分...........31圖2-23 手續

程序...........32圖2-24 注射角度須進入到翼狀下頜骨...........33圖2-25 針頭插入注射點...........33圖2-26 利用彎曲注射器針頭插入注射點...........34圖2-27 初步檢查得到的全景X光攝影檢查結果...........35圖2-28 CBCT結果...........36圖2-29 第二次CBCT...........37圖2-30 下牙槽神經（IAN）...........38圖2-31 左側下牙槽神經感知不足或缺失之區域...........39圖3-1 研究流程...........40圖3-2 3D列印打印結構.......

....46圖3-3 豬肉嘴邊肉部位...........47圖3-4 硬度測試樣本...........47圖3-5 韌度測試樣本...........47圖3-6 精度計重器...........48圖3-7 肖氏硬度計...........49圖3-8 硬度計工作原理...........49圖3-9 數顯式推拉力計...........50圖3-10 推拉力計工作原理...........50圖4-1 訪談牙醫師...........57圖4-2 實驗設備...........60圖4-3 牙醫師實際操作過程...........61圖4-4 訪談過程...........66圖4-5

矽膠硬度測試...........71圖4-6 豬肉硬度測試...........72圖4-7 硬度測試點...........72圖4-8 矽膠00-30與豬肉的硬度差...........74圖4-9 矽膠00-50與豬肉的硬度差...........75圖4-10 35%矽膠3D列印與豬肉的硬度差...........76圖4-11 50%矽膠3D列印與豬肉的硬度差...........77圖4-12 65%矽膠3D列印與豬肉的硬度差...........78圖4-13 80%矽膠3D列印與豬肉的硬度差...........79圖4-14 矽膠韌度測試...........80圖4-1

5 豬肉韌度測試...........80圖4-16 矽膠3D列印35%的韌度測試圖...........81圖4-17 矽膠3D列印50%的韌度測試圖...........81圖4-18 矽膠3D列印65%的韌度測試圖...........82圖4-19 矽膠3D列印80%的韌度測試圖...........82圖4-20 矽膠0030的韌度測試圖...........83圖4-21 矽膠0050的韌度測試圖...........83圖4-22 豬肉牙齦的韌度測試圖...........84圖4-24 豬肉牙肉肌肉組織的韌度測試圖...........84圖4-25 各矽膠與豬肉的牙齦硬度差.

..........88圖5-1 下顎骨骼及牙齒STL檔...........90圖5-2 3D列印之下顎骨骼及牙齒...........90圖5-3 3D矽膠3D列印仿真牙肉組織示意圖...........91圖5-4 矽膠3D列印仿真牙肉組織...........91圖5-5 互動設計示意圖...........92圖5-6 阻生智齒仿真教具...........92圖5-7 使用者測試過程...........94表目錄表2-1 調查問題與回饋...........10表2-2 外科手術模擬模型的弱點...........11表2-3 測試材質樣品...........15表2-4 觸覺

相似誤差值...........16表2-5 材質誤差值比較...........17表3-1 測試材料樣本...........46表4-1 使用者測試實驗人員列表...........62表4-2 摸起來與人體牙齦之硬度的滿意度...........62表4-3 摸起來與人體牙齦的彈性滿意度...........63表4-4 針頭插入之仿真質感...........63表4-5 針頭拔出之仿真質感...........64表4-6 刀片切開之仿真質感...........64表4-7 縫合之仿真質感...........65表4-8 整體仿真之各個材料排名...........65表4-9

硬度測試結果...........73表4-10 矽膠00-30與豬肉的硬度差...........73表4-11 矽膠00-50與豬肉的硬度差...........74表4-12 35%矽膠3D列印與豬肉的硬度差...........75表4-13 50%矽膠3D列印與豬肉的硬度差...........76表4-14 65%矽膠3D列印與豬肉的硬度差...........77表4-15 80%矽膠3D列印與豬肉的硬度差...........78