Produce的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列問答集和資訊懶人包

Applied Heath Care Analytics: Enabling Transformative Health Care Through Data Science, Machine Learning, and Cognitive Computin

為了解決Produce的問題，作者Albert, Mark/ Petrov, Plamen/ Ronanki, Rajeev 這樣論述：

The healthcare systems in the US and globally are undergoing a period of rapid transformation. Medical technology breakthroughs, economic pressures and demographic trends are driving that transformation, but key enablers and catalysts for those changes are advancements in Analytics, Data Science,

Cognitive Computing, and Machine Learning. Massive volumes of data are created during regular healthcare administration, delivery, and research operations; additionally, outside the medical community people produce data as part of their daily activities and social interactions that can be mined for

medical use. How can this data be put to use in an ethical way respecting privacy and security to achieve the goal of high quality, accessible and affordable Healthcare? Advanced analytics and cognitive computing are a big part of the answer. In Applied Heath Care Analytics, the authors provide a c

oncise yet comprehensive review of the key enabling tech and explain how those technologies are becoming the backbone of the Healthcare of tomorrow.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Produce的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Crime Fiction in the Age of #metoo

為了解決Produce的問題，作者Beyer, Charlotte 這樣論述：

Crime Fiction in the Age of #MeToo presents a compelling and timely fourth-wave feminist reading of crime fiction in the age of #metoo. The book explores four major fourth-wave feminist focal points, #metoo, rape culture/reclaim the night, toxic masculinity, and LBGTQ+ perspectives. These topics

have been the subject of intense feminist scrutiny and campaigning, and this attention is reflected in contemporary crime fiction and its generic and thematic preoccupation with such topics.The book opens with a chapter presenting an overview of existing critical perspectives and feminist debates, d

emonstrating how fourth-wave feminist ideas and debates are generating fresh ways of reading past crime texts, and new ways of reading new crime fictions. The chapter also outlines the book’s methodology. Each of the four main chapters examining these issues will use the critical vocabulary and conc

epts from discourses of resistance to present new readings of recently published crime fictions, and to reassess canonical works and authors in order to produce new compelling critiques of gender and genre.Through a focus on actively reading and engaging with crime literature, Crime Fiction in the A

ge of #MeToo will redress this significant gap in knowledge and meet a substantial need in scholarly debates for a fourth-wave feminist analysis of crime fiction which draws links between literature and ongoing urgent social and cultural debates.

電信業採用電信支付對經營策略影響之研究

為了解決Produce的問題，作者朱紹綺 這樣論述：

科技發展的日新月異，行動支付也因各行各業轉型發展已逐漸市場飽和，新冠疫情的爆發更是讓無接觸支付迅速的提升使用率。根據金管會公布2021年普惠金融衡量指標的結果2020年台灣每10萬成年人平均行動支付交易有243萬筆，年成長率近六成。小額支付對電信業者來說已是穩定的營收效益，為因應科技的變化及消費型態的改變，轉型推出電信支付2.0，增加更多的服務亦可使消費者輕易透過電信支付完成帳單繳費、儲值、付款。現在4家電信業者現行電信支付型態相似，以優先推出跨境電信支付之Ｇ公司作為研究訪談對象，以訪談法為主要研究方法藉由半結構式訪談、行銷4P分析及SWOT優劣分析來探討Ｇ公司電信支付之經營策略。研究發現，

個案公司推出創新3.0電信支付，再利用與政府合作科專項目得到相關資源進而提升服務品質與競業產生產品服務差異，行銷層面上，利用本身擁有多種媒體資源及超過500萬訂閱會員數提升產品知名度。推出跨境支付後，雖因疫情限制無法達到目標成效，現今疫情趨緩國境陸續解禁跨境支付應用可望達到目標成效，期望本研究可供個案公司電信支付永續經營之參考。