Hyper的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列問答集和資訊懶人包

That Time We Ate Our Feelings: Comfort Food from the Heart: From the Creators of #coronakitchen

為了解決Hyper的問題，作者Lucas, Lisa,Mansini, Debrianna 這樣論述：

Lisa Lucas is a writer, producer, and actor who has produced and written more than thirty television series including for ABC’s The Bachelorette, Bravo’s Work of Art, and NBC’s Emmy-winning My 1st Time. In 2017, she produced the Emmy-nominated feature documentary Defending the Fire. She is also an e

xecutive producer and principal partner in LikeMinds, a production company based in Santa Fe, New Mexico, that creates content for documentary and scripted television series, short films, and independent features. Lisa has received professional theatrical training from the National Theatre Institute

at the Eugene O’Neill Theatre Center in Waterford, Connecticut, and studied Shakespearean theater at the Guildhall School for Music and Drama in London. For some reason, she is frequently cast in roles of either unfortunate victims of wrong place at the wrong time situations, like in NBC’s The Nigh

t Shift, or hyper pious parochial school nuns like in the independent upcoming 2021 short film The Holy Word. In 2020, Lisa and Debrianna Mansini launched Corona Kitchen, an unscripted nightly cooking show on Facebook and YouTube Live. She lives in Santa Fe, New Mexico.Debrianna Mansini is an actor

, writer, and activist who is known for her role as Fran in AMC’s Breaking Bad and Better Call Saul, and playing opposite Oscar winner Jeff Bridges in Crazy Heart. She trained at the Circle in the Square Theatre School in New York City before launching Tin Roof Productions, which later became the Sa

nta Fe Performing Arts Company. Debrianna has worked off-Broadway in New York and has toured on stage throughout the United States in her critically acclaimed show The Meatball Chronicles. Debrianna and her husband, David Forlano, won the Earth Keepers Award for Best Sustainable Video for their docu

mentary short Earth Ships of Taos, whichwas shown at the Downtown Los Angeles Film Festival, and several of their documentary shorts have aired on Al Gore’s cable network, Current TV. In 2010, Debrianna’s children’s short, Picking Up Feets, was selected for the International Women in Film Festival.

In 2020, Debrianna and Lisa Lucas launched Corona Kitchen, an unscripted nightly cooking show on Facebook and Youtube Live. She lives in Santa Fe, New Mexico.

Hyper進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Hyper的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Hyperlocal: Place Governance in a Fragmented World

為了解決Hyper的問題，作者 這樣論述：

An examination of how the (hyper)local is the locus of real changeMany of America’s downtowns, waterfronts, and innovation districts have experienced significant revitalization and reinvestment in recent years, but concentrated poverty and racial segregation remain persistent across thousands of

urban, suburban, and rural neighborhoods. The coronavirus pandemic magnified this sustained and growing landscape of inequality.Uneven patterns of economic growth and investment require a shift in how communities are governed and managed. This shift must take into account the changing socioeconomic

realities of regions and the pressing need to bring inclusive economic growth and prosperity to more people and places.In this context, place-based (＂hyperlocal＂) governance structures in the United States and around the globe have been both part of the problem and part of the solution. These organi

zations range from community land trusts to business improvement districts to neighborhood councils. However, very little systematic research has documented the full diversity and evolution of these organizations as part of one interrelated field. Hyperlocal helps fill that gap by describing the cha

llenges and opportunities of ＂place governance.＂The chapters in Hyperlocal explore both the tensions and benefits associated with governing places in an increasingly fragmented--and inequitable--economic landscape. Together they explore the potential of place governance to give stakeholders a struct

ure through which to share ideas, voice concerns, advocate for investments, and co-design strategies with others both inside and outside their place. They also discuss how place governance can serve the interests of some stakeholders over others, in turn exacerbating wealth-based inequities within a

nd across communities. Finally, they highlight innovative financing, organizing, and ownership models for creating and sustaining more effective and inclusive place governance structures.The authors hope to provoke new thinking among place governance practitioners, policymakers, private sector leade

rs, urban planners, scholars, students, and philanthropists about how, why, and for whom place governance matters. The book also provides guidance on how to improve place governance practice to benefit more people and places.

基於工件運動配置與環境限制之機器人冗餘度設計與路徑優化抽樣演算法

為了解決Hyper的問題，作者賴振豪 這樣論述：

由於機械手臂在運動上的多功能性與成本效益，越來越多的加工任務利用它們來執行。為了滿足工件或工具的運動軌跡需求，並且保證加工品質，機器人運動軌跡的複雜性可能太高而無法產生可行的路徑規劃。主要的原因通常是機器人的自由度不足，無法避免奇異點或環境約束。直觀地向機器人添加更多關節並非一個好的解法，因此如何增加機器人冗餘自由度成為一個實際問題。換句話說，添加機器人的冗餘自由度必須考慮任務的運動配置、工具和環境約束。在本文中，提出了一種同時解決機器人的冗餘自由度設計和路徑規劃優化的新方法。機器人冗餘自由度分為兩種類型：設計自由度（design DOF）和運動自由度（motion DOF）。前者代表加工系

統的配置，例如夾具設計和工具/工件放置。後者代表整體運動規劃的參數，包括機器人和周邊設備。針對機器人冗餘自由度的設計和優化路徑規劃的問題，本文以設計自由度與運動自由度開發了不同約束條件下的遞迴優化架構。這個架構在幾何空間下使用取樣的方法在有限時間內搜索優化的解決方案。它的效果透過兩種的案例驗證，機器人研磨和機器人摺邊加工。這兩種案例的模擬結果分別降低了21.73% 和 58.81% 的成本。而且，後者在實驗中降低了55.434%的成本。這個實驗的結果透過視覺感測以平均3.26毫米的精度誤差加以驗證。