Follow up的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列問答集和資訊懶人包

Liverpool English

為了解決Follow up的問題，作者Watson, Kevin,Honeybone, Patrick,Clark, Lynn 這樣論述：

The Dialects of English series provides concise, accessible, authoritative and up-to-date documentation for varieties of English, including English-based pidgins and creoles, from all over the English-speaking world. Written by experts who have conducted first-hand research, the volumes are the m

ost obvious starting point for readers who would like to know more about a particular regional, urban or ethnic variety. The volumes follow a common structure, covering the context in which one clearly defined variety of English (or a number of closely related varieties) has been established as well

as their phonetics and phonology, morphosyntax, lexis and social history. Each volume concludes with an annotated bibliography and some sample texts. Previous volumes are listed below. Recent and forthcoming volumes are listed on the Volumes tab. Robert McColl Millar, Northern and Insular Scots (20

07) David Deterding, Singapore English (2007) Jennifer Hay, Margaret A. Maclagan & Elizabeth Gordon, New Zealand English (2008) Sailaja Pingali, Indian English (2009) Karen P. Corrigan, Irish English, Volume 1: Northern Ireland (2010) Sandra Clarke, Newfoundland and Labrador English (2010) Jane

Setter, Cathy S. P. Wong & Brian H. S. Chan, Hong Kong English (2010) Joan C. Beal, Lourdes Burbano Elizondo & Carmen Llamas, Urban North-Eastern English: Tyneside to Teeside (2012) Urszula Clarke & Esther Asprey, West Midlands English: Birmingham and the Black Country (2012) Advisory Bo

ard: David Britain (University of Bern, Switzerland) Kathryn Burridge (Monash University, Australia) Jenny Cheshire (Queen Mary University of London, United Kingdom) Alexandra D’Arcy (University of Victoria, Canada) Lisa Lim (The University of Hong Kong, China) Rajend Mesthrie (University of Cape To

wn, South Africa) Peter L. Patrick (University of Essex, United Kingdom) Peter Trudgill (University of Fribourg, Switzerland) Walt Wolfram (North Carolina State University, USA) To discuss your book idea or submit a proposal, please contact Natalie Fecher. For further publications in English linguis

tics see also our Topics in English Linguistics book series.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Follow up的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Both Sides of the Wire - Disaster at Dawn: Somme 1916: Preliminaries and First Moves

為了解決Follow up的問題，作者Cave, Nigel/ Sheldon, Jack 這樣論述：

Both Sides of the Wire is the first in a new series of battlefield guides that looks at the fighting on the Western Front, chiefly in the sectors in which the British Expeditionary Force was engaged. In these books, Nigel Cave and Jack Sheldon will look at engagements from both the allied and Ger

man perspective; at the end of each chapter there will be a tour section so that readers can place themselves in the best vantage points to follow the action that is described on the ground and which is directly related to the narrative account that will form the bulk of each chapter. This book deal

s with the Somme up to and including the first day or two of the infantry assault on 1 July. In addition to the familiar British sector, the authors intend to cover those parts of the Somme battlefield that were (largely) fought over by the French. Although there is much to see of the 'French' Secto

r, it is generally poorly served by published guides despite the fact that there are numerous signs of the Great War of the ground, many accessible to the public. With the concentration on 1st July and the subsequent months, there is relatively little about what happened on the Somme from the establ

ishment of the line there in October 1914 to the summer 1916 offensive. For example, this involved extensive mine warfare, of which very few traces remain, but for which there is excellent contemporary mapping and some useful accounts. Because of the considerable amount of literature already availab

le on the British sector of the Somme, the authors will be concentrating on particular aspects - areas selected include: Gommecourt (56th London Division); Serre (the French attacks of June 1915); the Heidenkopf; raids prior to I July around Beaumont Hamel; the Schwaben Redoubt, the German defence p

lan and what happened on the day; the Glory Hole and the fighting there from December 1914; the area around King George's Hill, near Fricourt; the attacks and counter attacks at Montauban on 1 - 3 July 1916; a very successful limited German assault at Feuilleres in January 1916; the line at Dompierr

e and Fey, in particular mine warfare (and also some coverage of the brief tenure of the line in this area by the British in the autumn of 1915). The book is aimed at anyone with an interest in the war, in the Somme in particular and, whilst acting as a guide, it will also be of value to those who c

annot get to the Somme themselves, with the authors aiming at a more balanced understanding of what happened and explaining the outcomes at the various locations.

運動訓練與停止訓練對中老年人骨骼肌氧合能力與身體功能表現之影響

為了解決Follow up的問題，作者杨永 這樣論述：

運動是一種改善中老年人骨骼肌氧合能力、提高肌肉力量並最終影響整體身體功能表現的有效方式。然而，較少的研究評估不同運動類型之間訓練效益的差異。此外，由於中老年人生病、外出旅行與照顧兒童等原因，迫使運動鍛煉的中斷。如何合理安排運動訓練的週期、強度與停訓週期，以促使中老年人在未來再訓練快速恢復以往訓練效益，目前亦尚不清楚。本文以三個研究建構而成。研究I：不同運動訓練模式對中老年人的骨骼肌氧合能力、肌力與身體功能表現的影響。以此探討50歲及以上中老年人進行每週2次為期8週的爆發力、阻力訓練以及心肺訓練在改善中老年人肌肉組織氧合能力、與肌肉力量身體功能效益的差異。我們的研究結果表明：爆發力組在改善下肢

肌力、最大爆發力與肌肉品質方面表現出較佳的效果。心肺組提高了30s坐站測試成績並減少了肌肉耗氧量，從而改善了中老年人在30s坐站測試期間的運動經濟性。年紀較高的肌力組則對於改善平衡能力更加有效。此外，三組運動形式均有效改善了中老年人人敏捷性。研究 Ⅱ：停止訓練對運動訓練後中老年人肌力與身體功能表現的影響：系統性回顧與meta分析。本研究欲探討停止訓練對運動訓練後中老年人肌力與身體功能表現訓練效益維持的影響。我們的研究結果表明：訓練期大於停止運動訓練期是肌力維持的重要因素。若訓練期