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運用仿生支架進行骨軟骨修復組織工程的生物設計策略

為了解決Additive effect vs s的問題，作者Swathi Nedunchezian 這樣論述：

Acknowledgment iii摘要 vAbstract viiList of figures xiii1. Chapter One 1Introduction 11.1 Problem statement 11.1.1 Articular cartilage 31.1.2 Structure and composition of articular cartilage 31.1.3 Articular cartilage defect 51.2. Surgical techniques for cartilage and Osteochondral repair

currently in use 61.2.1 Bone marrow techniques 61.2.2 Mosaiplasty 81.2.3 Autologous chondrocyte implantation method 91.2.4 Matrix induced autologous chondrocyte implantation 111.3. Tissue engineering approaches to Osteochondral defect repair 121.3.1 Scaffold and hydrogel-based cell delivery 1

41.4. Cell source for tissue engineering purposes 161.4.1 Chondrocyte cells 161.4.2 Adult somatic stem cells 171.4.3 Bone marrow-derived stem cell (BMSCs) 181.4.4 Adipose-derived stem cells (ADSCs) 191.5 Scaffolds and hydrogels for tissue engineering 211.5.1 Natural hydrogels in cartilage tiss

ue engineering 251.6. Crosslinking of hydrogel for tissue engineering purpose 291.6.2 Silicon-dioxide Nanoparticle as crosslinkers in tissue engineering 341.6.3 Interaction of SiO2 nanoparticle with adipose-derived stem cells 361.7 Bio ceramics for Osteochondral tissue engineering and regenerati

on 371.7.1 Bio ceramics in Tissue engineering applications 371.7.2 Applications of bioceramics in Osteochondral tissue engineering 391.8 Research Objectives 421.8.1 The specific aims of this thesis are as follows: 43Chapter Two 44Characteristic and chondrogenic differentiation analysis of hybr

id hydrogels comprise of hyaluronic acid methacryloyl (HAMA), gelatin methacryloyl (GelMA), and the acrylate functionalized nano-silica crosslinker 442.1 Introduction 442.2 Materials and methods 522.2.1 Materials 522.2.2 Synthesis of HAMA hydrogel 522.2.4 Synthesis of acrylate functionalized nS

i crosslinker (AFnSi) 532.2.5 Identification of the synthesis HAMA and GelMA 542.2.6 Production of hybrid hydrogels 552.2.7 Identification of the synthesis AFnSi cross-linker 552.2.8 Fabrication of HG hybrid hydrogels 562.2.9.Swelling ratio evaluation 562.2.10 The microstructure morphology ana

lysis 572.2.11 Mechanical properties evaluation 572.2.12 In vitro degradation assay by hyaluronidase 582.2.13 Isolation and culturing of hADSCs 592.2.14 Cell viability assay 602.2.15 Chondrogenic marker gene expression 612.2.15 Quantification of DNA, sGAG deposition and collagen type Ⅱ synthes

is 622.2.16 Statistical analysis 632.3. Results and Discussion 632.3.1.Identification of the synthesis HAMA and GelMA 632.3.2 Identification of the AFnSi crosslinker 672.3.3 Swelling ratio of HG hybrid hydrogels 702.3.4 Morphological examination of HG hybrid hydrogels 722.3.5 Compressive stud

y of HG hybrid hydrogels 752.3.6.Viscoelastic property of HG hybrid hydrogel 782.3.7. Degradation study of HG hybrid hydrogels 812.3.8.Cell viability evaluation of hADSCs on HG hybrid hydrogels 822.3.8. Chondrogenic differentiation ability of HG hybrid hydrogels 852.4. Conclusion 90Chapter Thr

ee 92Multilayer-based scaffold for Osteochondral defect regeneration in the rabbit model 923.1 Introduction 923.2 Materials and methods 963.2.1 Preparation and Characterization of the 3D bioceramic scaffold by DLP method 963.2.2 Cell isolation and culture 973.2.3 Fabrication of the cell-laden

hydrogel/ 3D bioceramic scaffolds mimicking the Osteochondral tissue. 983.2.4 Surgery 983.2.5 Macroscopic Examination 993.2.6 Tissue Processing for paraffin block 993.2.7 Histological and Immunohistochemical Evaluation 1003.2.8 Masson’s trichrome stain 1013.3 Results and discussion 1023.3.1 C

haracterization of the 3D bioceramic scaffold by DLP method 1023.3.2 Fabrication of the hydrogel with hADSCs into the 3D bioceramic scaffold 1043.3.3 In-vivo studies using rabbit as an animal model 1053.3.5 Histological evaluation of neocartilage formation 1073.3.6 Masson’s trichrome staining an

alysis for neocartilage formation 1093.4. Conclusion 110Chapter four 1104.1 General discussion 1124.2 Future work 1134.2.1 Macroscopic Observation of neocartilage formation for 8 weeks 1145.Reference 115

學業自我概念之大魚小池效應與學業成就關係探究：以TIMSS 2019為例的跨國多層次分析

為了解決Additive effect vs s的問題，作者林青松 這樣論述：

本研究使用2019國際數學和科學研究趨勢（TIMSS 2019）的數據，以檢驗納入統計的44個國家或地區中，八年級學生的學業自我概念之大魚小池效應與學業成就關係。大魚小池效應(Big Fish-Little-Pond-Effect)，係指當所處群體的平均能力較高，學生會因為與同儕的社會比較而產生較低的學業自我概念；反之然當所處群體的平均能力較低，學生則產生較高的學業自我概念。主要研究目的歸納如下：(一)探討學生數學自我概念對於數學學業成就的影響。(二)探討個體與班級層面之數學學業成就對於學生的數學學業自我概念的影響。(三)探討個體層面之數學學業成就、知覺相對位階(perceived rela

tive standing對學生的學業自我概念中之BFLPE的影響。據此，本研究提出三個研究假設模型，第一個統計模型是數學自我概念的驗證性因素分析（Confirmatory Factor Analysis, CFA）模型。第二個統計模型是Lüdtke et al.(2008)提出的多層次潛在共變項模型(multilevel latent covariate model)的擴展。在第三個統計模型中，與先前的研究一致(Wang＆ Bergin,2017，Huguet et al.,2009，Wang, 2015)，加入知覺相對位階以作為組內層次數學自我概念的附加預測因子。研究結果顯示：(一)班級間

平均數學學業自我概念有顯著不同。(二)學生個人與班級之數學學業成就對學生的數學學業自我概念有顯著預測力。(三)學生個人之數學學業成就、知覺相對位階對學生的數學學業自我概念有顯著的預測力。本研究僅基於研究的相關發現與研究過程所遇挑戰提出後續研究的建議，依內容分為對教育實務方面與對後續欲進行類似取向的研究提出相關議題之建議，期能將研究結果提供教育行政主管機關、學校行政人員、教師及未來研究者作為參考。