7-11 line point回饋的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列問答集和資訊懶人包

環狀核糖核酸hsa_circ_0000190會促進非小細胞肺癌的發生並透過調升分泌之PD-L1而影響腫瘤逃脫免疫系統

為了解決7-11 line point回饋的問題，作者羅永鴻 這樣論述：

中文摘要................................................i英文摘要................................................ii目錄....................................................iv圖目錄..................................................vii表目錄..................................................viii第一章 緒論.................

............................1第二章 研究目的.........................................4第三章 研究方法.........................................53.1 Patient Population.................................53.2 Cell Culture.......................................63.3 RNA Isolation and qRT-PCR..........................63.4

qRT-PCT and RT-ddPCR for Detecting Plasma circRNA..73.5 RNA-Seq............................................83.6 Cell and Plasmid Preparation for Overexpressing Circular RNA....................................................83.7 Transfection with Small-Interfering RNA (siRNA)....93.8 Cell Prolifera

tion Assay...........................93.9 Migration and Invasion.............................93.10 Wound-Healing Assay...............................103.11 Animal Experiments................................103.12 Western Blotting Analysis.........................113.13 RNA Extraction and RT-qPCR....

....................123.14 Enzyme-Linked Immunosorbent Assay.................133.15 Evaluation of LC Treatment Efficacy...............133.16 Statistical Analysis..............................13第四章 結果.............................................144.1 Identification of Potential Secretory circRNA Biom

arker Candidates Using RNA-Seq...............................144.2. Validation of Expression of hsa_circ_0000190 and hsa_circ_0001649 in LC Cell Lines......................174.3 RT-ddPCR Detection of hsa_circ_0000190 and hsa_circ_0001649 Secreted by LC Cell Lines and in Human Blood Plasma...........

......................................194.4 Expression of hsa_circ_0000190 and hsa_circ_0001649 in LC Patients with Different Stages and Tumor Sizes.........214.5 Plasma Levels of Hsa_circ_0000190 Negatively Correlate with the Response to Immunotherapy.....................254.6 Monitoring the Treatm

ent Response by Plasma Levels of circRNAs in LC Patients Receiving Immunotherapy........284.7 Bioinformatics Analysis of Potential Downstream Network for Hsa_circ_0000190 and Hsa_circ_0001649 in LC........314.8 Overexpression of hsa_circ_0000190 Promoted Tumorigenesis of NSCLC In Vitro..............

........................324.9 Knockdown of hsa_circ_0000190 Hindered Tumorigenesis of NSCLC In Vitro.........................................354.10 Overexpression of C190 Enhanced Tumor Growth In Vivo...................................................374.11 Nanoparticle-Wrapped, siRNA-Mediated C190

Knockdown Inhibited Tumor Growth In Vivo.........................394.12 Interaction among hsa_circ_0000190, microRNA, and Various Immune Checkpoints.............................414.13 PD-L1, CD155, CD80, FGL1, and CD70 Were Expressed in A549 Cells.............................................434.14 O

verexpression of hsa_circ_0000190 Regulated Expression of Immune Checkpoints In Vitro.........................434.15 The Overexpression of hsa_circ_0000190 Promoted Expression of Specific Immune Checkpoint mRNAs in NSCLC Cells..................................................434.16 The Knockdown of

hsa_circ_0000190 by siRNA Impeded Expression of Specific Immune Checkpoint mRNAs in NSCLC Cells..................................................454.17 Overexpression of hsa_circ_0000190 Increased the Expression and Secretion of Soluble PD-L1 in NSCLC Cell Lines and May Be Associated with Decreased

Efficacy of Anti-PD-1 Antibody...............................................47第五章 討論.............................................49第六章 結論.............................................52參考文獻................................................53附錄....................................................63