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Broken Glory: The Final Years of Robert F. Kennedy

為了解決dc的問題，作者Sanders, Ed 這樣論述：

Ed Sanders is a poet and performer whose roots go back to the Beats and early Grove Press. He was active in the antiwar movement during the Vietnam War. He began publishing the mimeographed magazine Fuck You! a Magazine of the Arts in 1962 and in 1965, started the Peace Eye Bookstore on Manhattan’s

Lower East Side, which became a center for countercultural and antiwar activities. He was a founding member of the satiric folk-rock band Fugs and also of the Yippies. He helped found the underground newspaper The East Village Other and wrote numerous articles for the Underground Press network. He h

as received Guggenheim and National Endowment of the Arts Fellowships as well as a poetry fellowship from the Foundation for Contemporary Performing Arts. He is the author of numerous works of poetry and nonfiction, including Thirsting for Peace in a Raging Century: Selected Poems, 1961-1985, winner

of an American Book Award, 1968: A History in Verse, and the nonfiction work The Family, about Charles Manson and his dystopic communal family, on which the new movie Charlie Says is based. He lives in Woodstock, New York. Rick Veitch is a lifelong cartoonist. He illustrated Swamp Thing while at DC

Comics and is the author of innumerable alternative comic books, including Can’t Get None and the Eisner Award-nominated Brat Pack, The Maximortal, Rare Bit Fiends, and The Spotted Stone. He lives in West Townsend, Vermont.

dc進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決dc的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

DC First Words for Super Heroes

為了解決dc的問題，作者Katz, Morris 這樣論述：

Morris Katz is the author of My First Book of Superpowers, Even Super Heroes Sleep, My First Book of Super-Villains, Super Heroes Have Friends Too, DC Super Heroes Who’s Who, The Big Book of Superpowers, and The Big Book of Super-Villains. Illustrations are classic DC comic book art

無橋式功因修正轉換器研製

為了解決dc的問題，作者黃禎岳 這樣論述：

本論文目的在研製一無橋式功因修正轉換器，硬體電路以圖騰柱型功率因數修正電路為核心，利用外迴路電壓感測電路與內迴路電流感測電路完成本控制。本研究採用平均電流控制法來實現功率因數修正功能。平均電流控制法以雙迴圈PI控制器來實現，由輸入電壓極性與波形角度傳給雙迴圈PI控制系統運算，外迴圈PI控制器控制電壓，內迴圈PI控制器控制電流，軟體是以瑞薩電子公司生產的R5F562TAADFP數位訊號處理器實現，經實測結果顯示功率因數可達0.98以上，總諧波失真率最大為11.644%。證明本控制器可達功率因數修正的效果。